Very low-calorie ketogenic diet may allow restoring response to systemic therapy in relapsing plaque psoriasis.

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URL: https://www.ncbi.nlm.nih.gov/pubmed/26559897

Journal: Obesity Research & Clinical Practice

Publication Date: 05/2016

Summary: Psoriasis is a chronic disease associated with overweight/obesity and related cardiometabolic complications. The link between these diseases is likely the inflammatory background associated with adipose tissue, particularly the visceral one. Accordingly, previous studies have demonstrated that in the long-term weight loss may improve the response to systemic therapies. We report a case report of a woman in her 40s suffering from relapsing moderate-to-severe plaque psoriasis and obesity-related metabolic syndrome, in whom adequate response to ongoing treatment with biological therapy (adalimumab) was restored after only 4 weeks of very low-calorie, carbohydrate-free (ketogenic), protein-based diet. Accordingly, through rapid and consistent weight loss, very low calorie ketogenic diet may allow restoring a quick response to systemic therapy in a patient suffering from relapsing psoriasis. This intervention should be considered in overweight/obese patients before the rearrangement of systemic therapy. Nonetheless, studies are required to evaluate whether very low calorie ketogenic diets should be preferred to common low-calorie diets to improve the response to systemic therapy at least in patients with moderate-to-severe psoriasis.

Key Takeaways

This case report suggest that a low calorie ketogenic diet that accelerates weight loss can restore the ability of the body to respond to therapy with adalimumab in someone with relapsing plaque psoriasis.

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