The ketone body β-hydroxybutyrate mitigates ILC2-driven airway inflammation by regulating mast cell function

Share This Post

URL: https://www.cell.com/cell-reports/fulltext/S2211-1247(22)01278-5?
Journal: Cell Reports
Publication Date: 09/2022
Summary: Ketone bodies are increasingly understood to have regulatory effects on immune cell function, with β-hydroxybutyrate (BHB) exerting a predominantly anti-inflammatory response. Dietary strategies to increase endogenous ketone body availability such as the ketogenic diet (KD) have recently been shown to alleviate inflammation of the respiratory tract. However, the role of BHB has not been addressed. Here, we observe that BHB suppresses group 2 innate lymphoid cell (ILC2)-mediated airway inflammation. Central to this are mast cells, which support ILC2 proliferation through interleukin-2 (IL-2). Suppression of the mast cell/IL-2 axis by BHB attenuates ILC2 proliferation and the ensuing type 2 cytokine response and immunopathology. Mechanistically, BHB directly inhibits mast cell function in part through GPR109A activation. Similar effects are achieved with either the KD or 1,3-butanediol. Our data reveal the protective role of BHB in ILC2-driven airway inflammation, which underscores the potential therapeutic value of ketone body supplementation for the management of asthma.

Key Takeaways

Ketone bodies produced during a ketogenic diet have an anti-inflammatory effect. These ketones have even been shown to decrease inflammation in the lungs by suppressing an inflammatory cell type called mast cells. Therefore, ketogenic diets can be used as a supplemental treatment for asthma.

Keto Helps Treat Asthma

Share This Post

Subscribe To Our Newsletter

Get Fun Carnivore Updates and inspirations

Leave a Comment

Your email address will not be published.

More To Explore

Effects of weight loss during a very low carbohydrate diet on specific adipose tissue depots and insulin sensitivity in older adults with obesity: a randomized clinical trial

URL: https://nutritionandmetabolism.biomedcentral.com/articles/10.1186/s12986-020-00481-9Journal: Nutrition & MetabolismPublication Date: 08/2020Summary: Weight loss resulting from consumption of a diet lower in CHO and higher in fat may be beneficial for older adults with obesity by depleting adipose tissue depots most strongly implicated in poor metabolic and functional outcomes and by improving insulin sensitivity and the lipid profile. Key Takeaways Older adults

Ketogenic Diet and Health

URL: https://www.lidsen.com/journals/icm/icm-06-02-015Journal: OBM Integrative and Complementary MedicinePublication Date: 04/2021Summary: Carbohydrate-restricted ketogenic diets (KD) were introduced in the mid-19th century as a weight loss method with a resurgence of its use in epilepsy treatment in the 1920’s. Research conducted over the last several years provides evidence that KD’s can confer beneficial effects for several chronic metabolic

Do You Want To Achieve your Optimal Health?

Join us for a free 30-date trial. Cancel Anytime.