Journal: Cell Reports
Publication Date: 09/2022
Summary: Ketone bodies are increasingly understood to have regulatory effects on immune cell function, with β-hydroxybutyrate (BHB) exerting a predominantly anti-inflammatory response. Dietary strategies to increase endogenous ketone body availability such as the ketogenic diet (KD) have recently been shown to alleviate inflammation of the respiratory tract. However, the role of BHB has not been addressed. Here, we observe that BHB suppresses group 2 innate lymphoid cell (ILC2)-mediated airway inflammation. Central to this are mast cells, which support ILC2 proliferation through interleukin-2 (IL-2). Suppression of the mast cell/IL-2 axis by BHB attenuates ILC2 proliferation and the ensuing type 2 cytokine response and immunopathology. Mechanistically, BHB directly inhibits mast cell function in part through GPR109A activation. Similar effects are achieved with either the KD or 1,3-butanediol. Our data reveal the protective role of BHB in ILC2-driven airway inflammation, which underscores the potential therapeutic value of ketone body supplementation for the management of asthma.
Travis improved focus, anxiety disorder, OCD, depression, psoriasis, and blood sugar on the carnivore diet
Travis is in Calgary, Canada, and was born with coarctation of the aorta, also nearly three months premature. He says there were “lots of complications because of that.” Travis explains, “I’ve had eight heart operations, and two gastrointestinal because my aorta was actually plumbed to my stomach artery. Because that got infected… it was a