Short-term sleep deprivation with exposure to nocturnal light alters mitochondrial bioenergetics in Drosophila

Share This Post

URL: https://www.sciencedirect.com/science/article/abs/pii/S0891584918307263
Journal: Free Radical Biology and Medicine
Publication Date: 05/2018
Summary: Many studies have shown the effects of sleep deprivation in several aspects of health and disease. However, little is known about how mitochondrial bioenergetics function is affected under this condition. To clarify this, we developed a simple model of short-term sleep deprivation, in which fruit-flies were submitted to a nocturnal light condition and then mitochondrial parameters were assessed by high resolution respirometry (HRR). Exposure of flies to constant light was able to alter sleep patterns, causing locomotor deficits, increasing ROS production and lipid peroxidation, affecting mitochondrial activity, antioxidant defense enzymes and caspase activity. HRR analysis showed that sleep deprivation affected mitochondrial bioenergetics capacity, decreasing respiration at oxidative phosphorylation (OXPHOS) and electron transport system (ETS). In addition, the expression of genes involved in the response to oxidative stress and apoptosis were increased. Thus, our results suggest a connection between sleep deprivation and oxidative stress, pointing to mitochondria as a possible target of this relationship.

Share This Post

Subscribe To Our Newsletter

Get Fun Carnivore Updates and inspirations

Leave a Comment

Your email address will not be published.

More To Explore

Ketogenic diet for weight loss

URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371871/Journal: Canadian Family PhysicianPublication Date: 12/2018Summary: Ketogenic diets can help patients lose about 2 kg more than low-fat diets do at 1 year, but higher-quality studies show no difference. Weight loss peaks at about 5 months but is often not sustained. Individual weight change can vary from losing 30 kg to gaining 10 kg

Vitamin D as a promising anticancer agent

URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3081446/Journal: Indian Journal of PharmacologyPublication Date: 04/2011Summary: Presence of vitamin D receptors in noncalcemic tissues and subsequent identification of its involvement in growth factor(s)-mediated cellular function suggested its probable beneficial role in genesis, progression and survival of cancerous growths. Data collected from both in vitro and in vivo studies are highly optimistic regarding its

Do You Want To Achieve your Optimal Health?

Join us for a free 30-date trial. Cancel Anytime.