Phase I/II multicenter ketogenic diet study for adult superrefractory status epilepticus

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URL: https://www.ncbi.nlm.nih.gov/pubmed/28179470

Journal: Neurology

Publication Date: 03/2017

Summary: To investigate the feasibility, safety, and efficacy of a ketogenic diet (KD) for superrefractory status epilepticus (SRSE) in adults. We performed a prospective multicenter study of patients 18 to 80 years of age with SRSE treated with a KD treatment algorithm. The primary outcome measure was significant urine and serum ketone body production as a biomarker of feasibility. Secondary measures included resolution of SRSE, disposition at discharge, KD-related side effects, and long-term outcomes. Twenty-four adults were screened for participation at 5 medical centers, and 15 were enrolled and treated with a classic KD via gastrostomy tube for SRSE. Median age was 47 years (interquartile range [IQR] 30 years), and 5 (33%) were male. Median number of antiseizure drugs used before KD was 8 (IQR 7), and median duration of SRSE before KD initiation was 10 days (IQR 7 days). KD treatment delays resulted from intravenous propofol use, ileus, and initial care received at a nonparticipating center. All patients achieved ketosis in a median of 2 days (IQR 1 day) on KD. Fourteen patients completed KD treatment, and SRSE resolved in 11 (79%; 73% of all patients enrolled). Side effects included metabolic acidosis, hyperlipidemia, constipation, hypoglycemia, hyponatremia, and weight loss. Five patients (33%) ultimately died. KD is feasible in adults with SRSE and may be safe and effective. Comparative safety and efficacy must be established with randomized placebo-controlled trials.

Key Takeaways

Supra-refractory status epilepticus is a seizure that lasts for > 24 hours despite anesthetic treatment. Inducing ketosis in 14 patients with supra-refractory status epileticus using ketogenic diet took two days, and 11 of the patients had resolution of the seizures and 5 died.

Ketogenic Diet Has Potential Use In Supra-Refractory Status Epilepticus

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