Is the restricted ketogenic diet a viable alternative to the standard of care for managing malignant brain cancer?

Share This Post

URL: https://www.sciencedirect.com/science/article/abs/pii/S0920121111002063?via%3Dihub

Journal: Epilepsy Research

Publication Date: 07/2012

Summary: Malignant brain cancer persists as a major disease of morbidity and mortality. The failure to recognize brain cancer as a disease of energy metabolism has contributed in large part to the failure in management. As long as brain tumor cells have access to glucose and glutamine, the disease will progress. The current standard of care provides brain tumors with access to glucose and glutamine. The high fat low carbohydrate ketogenic diet (KD) will target glucose availability and possibly that of glutamine when administered in carefully restricted amounts to reduce total caloric intake and circulating levels of glucose. The restricted KD (RKD) targets major signaling pathways associated with glucose and glutamine metabolism including the IGF-1/PI3K/Akt/Hif pathway. The RKD is anti-angiogenic, anti-invasive, anti-inflammatory, and pro-apoptotic when evaluated in mice with malignant brain cancer. The therapeutic efficacy of the restricted KD can be enhanced when combined with drugs that also target glucose and glutamine. Therapeutic efficacy of the RKD was also seen against malignant gliomas in human case reports. Hence, the RKD can be an effective non-toxic therapeutic option to the current standard of care for inhibiting the growth and invasive properties of malignant brain cancer.

Key Takeaways

Brain cancers can be thought of as a disease of energy regulation. They utilize glucose and glutamine to survive and grow. This is why standards of care may be outperformed by dietary approaches that stabilize the glucose input to the brain such as the ketogenic diet. Additionally a calorie restricted ketogenic diet may target the utilization of glutamine by the cancer. A calorie restricted ketogenic diet in mice with malignant brain cancer was shown to be anti-inflammatory, reduce invasion of the cancer, reduce access of cancer to nutrients by preventing blood vessel formation, and induce death of the cancer cells.

Brain Cancer Goes Away On Ketogenic Diet?!

Share This Post

Subscribe To Our Newsletter

Get Fun Carnivore Updates and inspirations

Leave a Comment

Your email address will not be published.

More To Explore

Meat and mental health: A meta-analysis of meat consumption, depression, and anxiety

URL: https://www.tandfonline.com/doi/full/10.1080/10408398.2021.1974336 Journal: Critical Reviews in Food Science and Nutrition Publication Date: 10/2021 Summary: In this meta-analysis, we examined the quantitative relation between meat consumption or avoidance, depression, and anxiety. in June 2020, we searched five online databases for primary studies examining differences in depression and anxiety between meat abstainers and meat consumers that offered a

Effect of Lower Versus Higher Red Meat Intake on Cardiometabolic and Cancer Outcomes: A Systematic Review of Randomized Trials

URL: https://annals.org/aim/fullarticle/2752326/effect-lower-versus-higher-red-meat-intake-cardiometabolic-cancer-outcomes Journal: Annals of Internal Medicine Publication Date: 10/2019 Summary: Low- to very-low-certainty evidence suggests that diets restricted in red meat may have little or no effect on major cardiometabolic outcomes and cancer mortality and incidence. Key Takeaways Restricting meat from the diet does not have positive effects on cardiometabolic disease or cancer mortality and incidence. There are

Do You Want To Achieve your Optimal Health?

Join us for a free 30-date trial. Cancel Anytime.