Dietary ketosis enhances memory in mild cognitive impairment

Share This Post

URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3116949/

Journal: Nuerobiology of Aging

Publication Date: 02/2012

Summary: We randomly assigned 23 older adults with Mild Cognitive Impairment to either a high carbohydrate or very low carbohydrate diet. Following the six-week intervention period, we observed improved verbal memory performance for the low carbohydrate subjects (p = 0.01) as well as reductions in weight (p < 0.0001), waist circumference (p < 0.0001), fasting glucose (p = 0.009), and fasting insulin (p = 0.005). Level of depressive symptoms was not affected. Change in calorie intake, insulin level, and weight were not correlated with memory performance for the entire sample, although a trend toward a moderate relationship between insulin and memory was observed within the low carbohydrate group. Ketone levels were positively correlated with memory performance (p = 0.04). These findings indicate that very low carbohydrate consumption, even in the short-term, can improve memory function in older adults with increased risk for Alzheimer’s disease. While this effect may be attributable in part to correction of hyperinsulinemia, other mechanisms associated with ketosis such as reduced inflammation and enhanced energy metabolism also may have contributed to improved neurocognitive function. Further investigation of this intervention is warranted to evaluate its preventive potential and mechanisms of action in the context of early neurodegeneration.

Key Takeaways

Low carbohydrate ketogenic diets showed improved memory, weight loss, blood sugar, and fasting insulin in adults with mild cognitive impairment. Further research is needed to determine whether the improvement is due to correction of high insulin levels, or the reduction in inflammation brought about by the ketosis.

Ketogenic Diet Improves Memory in Adults With Cognitive Impairment

Share This Post

Subscribe To Our Newsletter

Get Fun Carnivore Updates and inspirations

Leave a Comment

Your email address will not be published.

More To Explore

Meat and mental health: A meta-analysis of meat consumption, depression, and anxiety

URL: https://www.tandfonline.com/doi/full/10.1080/10408398.2021.1974336 Journal: Critical Reviews in Food Science and Nutrition Publication Date: 10/2021 Summary: In this meta-analysis, we examined the quantitative relation between meat consumption or avoidance, depression, and anxiety. in June 2020, we searched five online databases for primary studies examining differences in depression and anxiety between meat abstainers and meat consumers that offered a

Effect of Lower Versus Higher Red Meat Intake on Cardiometabolic and Cancer Outcomes: A Systematic Review of Randomized Trials

URL: https://annals.org/aim/fullarticle/2752326/effect-lower-versus-higher-red-meat-intake-cardiometabolic-cancer-outcomes Journal: Annals of Internal Medicine Publication Date: 10/2019 Summary: Low- to very-low-certainty evidence suggests that diets restricted in red meat may have little or no effect on major cardiometabolic outcomes and cancer mortality and incidence. Key Takeaways Restricting meat from the diet does not have positive effects on cardiometabolic disease or cancer mortality and incidence. There are

Do You Want To Achieve your Optimal Health?

Join us for a free 30-date trial. Cancel Anytime.