Carbotoxicity—Noxious Effects of Carbohydrates

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URL: https://www.cell.com/cell/fulltext/S0092-8674(18)30972-3?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867418309723%3Fshowall%3Dtrue

Journal: Cell

Publication Date: 10/2018

Summary: Modern nutrition is often characterized by the excessive intake of different types of carbohydrates ranging from digestible polysaccharides to refined sugars that collectively mediate noxious effects on human health, a phenomenon that we refer to as “carbotoxicity.” Epidemiological and experimental evidence combined with clinical intervention trials underscore the negative impact of excessive carbohydrate uptake, as well as the beneficial effects of reducing carbs in the diet. We discuss the molecular, cellular, and neuroendocrine mechanisms that link exaggerated carbohydrate intake to disease and accelerated aging as we outline dietary and pharmacologic strategies to combat carbotoxicity.

Key Takeaways

Excessive carbohydrate intake can lead to increased disease accelerated aging through multiple mechanisms. Ketogenic diets confer a health benefit by reducing excessive carbohydrates and have health and longevity benefits as well.

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