Alternate Day Fasting Improves Physiological and Molecular Markers of Aging in Healthy, Non-obese Humans

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URL: https://www.sciencedirect.com/science/article/abs/pii/S1550413119304292

Journal: Cell Metabolism

Publication Date: 09/2019

Summary: Caloric restriction and intermittent fasting are known to prolong life and healthspan in model organisms, while their effects on humans are less well studied. In a randomized controlled trial study (ClinicalTrials.gov identifier: NCT02673515), we show that 4 weeks of strict alternate day fasting (ADF) improved markers of general health in healthy, middle-aged humans while causing a 37% calorie reduction on average. No adverse effects occurred even after >6 months. ADF improved cardiovascular markers, reduced fat mass (particularly the trunk fat), improving the fat-to-lean ratio, and increased β-hydroxybutyrate, even on non-fasting days. On fasting days, the pro-aging amino-acid methionine, among others, was periodically depleted, while polyunsaturated fatty acids were elevated. We found reduced levels of ICAM-1 (an age-associated inflammatory marker), low-density lipoprotein, and the metabolic regulator triiodothyronine after long-term ADF. These results shed light on the physiological impact of ADF and supports its safety. ADF could eventually become a clinically relevant intervention.

Key Takeaways

Alternate day fasting improves a variety of health markers including cardiovascular health, fat mass, lean mass, increased ketones, and decreased inflammation.

How Can Fasting Be Healthy??

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