A Ketogenic Diet Reduces Central Obesity and Serum Insulin in Women with Ovarian or Endometrial Cancer

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URL: https://pubmed.ncbi.nlm.nih.gov/30137481/
Journal: The Journal of Nutrition
Publication Date: 08/2018
Summary: In women with ovarian or endometrial cancer, a ketogenic diet (KD) results in selective loss of fat mass and retention of lean mass. Visceral fat mass and fasting serum insulin also are reduced by the KD, perhaps owing to enhanced insulin sensitivity. Elevated serum β-hydroxybutyrate may reflect a metabolic environment inhospitable to cancer proliferation. This trial was registered at www.clinicaltrials.gov as NCT03171506.

Key Takeaways

Women with ovarian cancer were able to utilize the ketogenic diet to lose fat without losing muscle mass. They were also able to reduce the fat surrounding their organs and improve metabolic markers such as insulin, insulin sensitivity, IGF-1. Additionally they had increased levels of ketone bodies, which may play a role in fighting cancer.

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